OESTROGEN FORMATION IN HUMAN FOETUSES PERFUSED WITH [14-14C]PROGESTERONE

ABSTRACT Four human foetuses of 16–20 weeks gestation were perfused via the umbilical vein with blood containing [4-14C]progesterone. Steroids were subsequently extracted from the livers, ovaries, adrenals and perfusates. Oestriol, containing a 14C-label was isolated and characterised from extracts...

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Bibliographic Details
Published inActa endocrinologica (Copenhagen) Vol. 75; no. 3; pp. 595 - 600
Main Authors Taylor, T, Coutts, J R, Macnaughton, M C
Format Journal Article
LanguageEnglish
Published Denmark 01.03.1974
Subjects
Adrenal Glands - analysis
Androstenedione - metabolism
Carbon Radioisotopes
Chromatography, Paper
Chromatography, Thin Layer
Estradiol - analysis
Estradiol - metabolism
Estriol - analysis
Estriol - biosynthesis
Estrone - analysis
Estrone - metabolism
Female
Fetus - metabolism
Gestational Age
Gonads - analysis
Humans
Liver - analysis
Male
Perfusion
PREGNANCY
Progesterone - metabolism
Radioisotope Dilution Technique
Testosterone - metabolism
Tritium
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Summary:ABSTRACT Four human foetuses of 16–20 weeks gestation were perfused via the umbilical vein with blood containing [4-14C]progesterone. Steroids were subsequently extracted from the livers, ovaries, adrenals and perfusates. Oestriol, containing a 14C-label was isolated and characterised from extracts of the livers, and in one case, the perfusate. Androstenedione, testosterone, oestrone and oestradiol were not present in any of the tissues in identifiable amounts. The results demonstrate that the mid-term foetus, can form oestriol from progesterone independently of placental aromatisation.
ISSN:0804-4643
0001-5598
1479-683X
DOI:10.1530/acta.0.0750595