Analysis of population genetic structure from Bucaramanga (Colombia) based on gene polymorphisms associated with regulation of blood pressure
Introduction: In spite nearly 40% of the variability in blood pressure can be explained by genetic factors, the identification of genes associated to essential high blood pressure is diffcult in populations where individuals have different genetic precedents; in these circumstances it is necessary t...
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Published in | Colombia medica (Cali, Colombia) Vol. 43; no. 2; pp. 154 - 161 |
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Main Authors | , , , , , , , |
Format | Journal Article |
Language | English |
Published |
Colombia
Universidad del Valle - Facultad de Salud
01.04.2012
Universidad del Valle |
Subjects | |
Online Access | Get full text |
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Summary: | Introduction: In spite nearly 40% of the variability in blood pressure
can be explained by genetic factors, the identification of genes
associated to essential high blood pressure is diffcult in populations
where individuals have different genetic precedents; in these
circumstances it is necessary to determinate whether the population is
sub-structured because this can bias studies associated with this
disease. Objectives: To determine the genetic structure of the
population in Bucaramanga from genetic polymorphisms associated with
the regulation of blood pressure: 448G>T, 679C>T y 1711C>T
from the gene kinase 4 of the dopaminergic receptor linked to the
protein G and Glu298Asp, -786T>C and the VNTR of the intron 4 of the
gene of endothelial nitric oxide. Methodology: A sample of 552
unrelated individuals was studied through analysis of Restriction
fragment length polymorphism. The allelic, haplotypic and genotypic
frequencies were calculated, the Hardy-Weinberg equilibrium was
determined and a molecular analysis of variance was performed to
determine the genetic structure. Results: 38 Haplotypes were
identified, with GCCTG4b as the most frequent (21.2%). The most diverse
polymorphism was 448G>T with a frequency of 49.9% for heterozygous.
The six polymorphisms were found in genetic equilibrium and genetic
structure of populations was not evidenced (FST = 0,0038). Conclusion:
The population studied does not present a genetic sub-structure and the
polymorphisms analyzed were found in genetic equilibrium, this
indicates that the population mixes randomly and there are no
sub-groups capable of affecting the results of the association studies. |
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Bibliography: | Conflict of interest: The authors declare no conflict of interest in this manuscript |
ISSN: | 0120-8322 1657-9534 |
DOI: | 10.25100/cm.v43i2.787 |