Multiple pruritic eruptions and hyperpigmentation

Laboratory evaluation showed unremarkable results for electrolytes, creatine kinase, antinuclear antibodies, erythrocyte sedimentation rate, C reactive protein. Histopathological analysis of a hand dorsum lesion showed epidermal hyperkeratosis and vacuolar degeneration of basal cells, with mild lymp...

Full description

Saved in:
Bibliographic Details
Published inBMJ (Online) Vol. 387; p. e079262
Main Authors Huang, Yu-Ying, Li, Xiao-Fang, Liu, Wei-Da
Format Journal Article
LanguageEnglish
Published England British Medical Journal Publishing Group 28.11.2024
BMJ Publishing Group LTD
Subjects
Angiogenesis
Antinuclear antibodies
Basal cells
C-reactive protein
Case reports
Chemotherapy
Creatine
Creatine kinase
Dermatitis
Dermis
Endgames
Erythema
Erythrocyte sedimentation rate
Granule cells
Hands
Hematological diseases
Hematology
Hydroxyurea
Hyperpigmentation
Kinases
Melanin
Side effects
Steroids
Sweat gland
Ulcers
Online AccessGet full text

Cover

More Information
Summary:Laboratory evaluation showed unremarkable results for electrolytes, creatine kinase, antinuclear antibodies, erythrocyte sedimentation rate, C reactive protein. Histopathological analysis of a hand dorsum lesion showed epidermal hyperkeratosis and vacuolar degeneration of basal cells, with mild lymphocytic infiltration, angiogenesis, presence of melanophages and melanin granules, and decrease of sweat glands in the dermis. Hydroxyurea dermopathy is characterised by spontaneous regression on discontinuation of hydroxyurea.310 In most patients, clinical manifestations improve within one to 12 months after stopping hydroxyurea without recurrence.5 A comprehensive evaluation of the severity of cutaneous symptoms and haematological disorders is needed to determine the appropriateness of stopping treatment with hydroxyurea.
Bibliography:Case Review
ObjectType-Article-1
SourceType-Scholarly Journals-1
ObjectType-Feature-2
content type line 14
ObjectType-Report-3
ObjectType-Case Study-4
content type line 23
ISSN:1756-1833
1756-1833
DOI:10.1136/bmj-2024-079262