Design and Evaluation of a Novel Gas Formation-Based Multiple-Unit Gastro-Retentive Floating Drug Delivery System for Quetiapine Fumarate
Purpose: To develop a gastro-retentive formulation of quetiapine fumarate in the form of floating minitablets. Methods: The system consisted of core units prepared by direct compression process, which were coated with three successive layers, namely, an inner seal coat, effervescent layer and an out...
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Published in | Tropical journal of pharmaceutical research Vol. 13; no. 4; p. 489 |
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Main Authors | , , , |
Format | Journal Article |
Language | English |
Published |
Nigeria
Pharmacotherapy Group, Faculty of Pharmacy, University of Benin, Benin City, Nigeria
18.09.2014
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Subjects | |
Online Access | Get full text |
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Summary: | Purpose: To develop a gastro-retentive formulation of quetiapine
fumarate in the form of floating minitablets. Methods: The system
consisted of core units prepared by direct compression process, which
were coated with three successive layers, namely, an inner seal coat,
effervescent layer and an outer polymeric layer of polymethacrylates.
Results: Mini-tablets coated with Eudragit RS 30D (5, 7.5 and 10%)
released ≤ 85% of the drug after 12 h, while those coated with
Eudragit RL 30D (5, 7.5 and 10%) released ≥ 85% drug within the
same period. Drug release kinetic studies showed that drug diffusion
fitted best to zero order and Higuchi models, indicating that drug
release was anomalous non-Fickian transport. In vivo gastric residence
time results indicate that the units remained in the stomach for about
6 h (n = 3). There was no significant change in dissolution profiles
before and after storage at 40°C and 75% RH for 6 months.
Conclusion: The developed floating mini-tablets of quetiapine fumarate
exhibit prolonged release for ≥12 h, and thus may improve
bioavailability and minimize fluctuations in plasma drug
concentrations. |
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ISSN: | 1596-5996 1596-5996 1596-9827 |
DOI: | 10.4314/tjpr.v13i4.1 |