Concurrent adrenocortical carcinoma and Conn's adenoma in a man with primary hyperaldosteronism. In vivo and in vitro studies

This is a report of a rare and unusual case of adrenal pathology. A patient presented with clinical and biological signs of primary aldosteronism and computed body tomography scan led to our suspecting the presence of a left adrenocortical carcinoma. The in vitro studies performed on the resected tu...

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Bibliographic Details
Published inActa endocrinologica (Copenhagen) Vol. 127; no. 2; pp. 189 - 192
Main Authors Touitou, Y, Boissonnas, A, Bogdan, A, Auzéby, A
Format Journal Article
LanguageEnglish
Published Denmark 01.08.1992
Subjects
Adenoma - complications
Adenoma - diagnosis
Adenoma - pathology
Adrenal Cortex Neoplasms - complications
Adrenal Cortex Neoplasms - diagnosis
Adrenal Cortex Neoplasms - pathology
Adrenal Glands - diagnostic imaging
Adrenal Glands - metabolism
Adrenal Glands - pathology
Adult
Glucocorticoids - metabolism
Humans
Hyperaldosteronism - complications
Hyperaldosteronism - diagnosis
Hyperaldosteronism - pathology
Male
Mineralocorticoids - metabolism
Tomography, X-Ray Computed
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Summary:This is a report of a rare and unusual case of adrenal pathology. A patient presented with clinical and biological signs of primary aldosteronism and computed body tomography scan led to our suspecting the presence of a left adrenocortical carcinoma. The in vitro studies performed on the resected tumour showed very low synthesis of mineralocorticoids and glucocorticoids. The patient could not be re-examined until 15 months later, when he still suffered hypertension; another tomography scan revealed a mass on the right adrenal gland. The studies performed on this second tumour confirmed the diagnosis of Conn's adenoma: active in vitro biosynthesis of 18-hydroxy-corticosterone and aldosterone from exogenous tritiated precursors.
ISSN:0804-4643
0001-5598
1479-683X
DOI:10.1530/acta.0.1270189