No association between asthma or allergy and the CCR5Δ 32 mutation

• Published in: Archives of disease in childhood Vol. 86; no. 6; pp. 426 - 427
• Main Authors: Nagy, A, Kozma, G T, Bojszkó, Á, Krikovszky, D, Falus, A, Szalai, C
• Format: Journal Article
• Language: English
• Published: London BMJ Publishing Group Ltd and Royal College of Paediatrics and Child Health 01.06.2002; BMJ
• Subjects: Allergic diseases; allergy; asthma; Biological and medical sciences; chemokine; General aspects. Genetic counseling; Immunopathology; Medical genetics; Medical sciences; Original; Respiratory and ent allergic diseases; Human; Immunopathology; Allergy; Respiratory disease; Exploration; Asthma; Atopy; Allele; Concomitant disease; Genetics; Obstructive pulmonary disease; Diagnosis; Mutation; Child; Comparative study
• ISSN: 0003-9888; 1468-2044
• DOI: 10.1136/adc.86.6.426

Aims: To investigate whether the presence of the CCR5Δ32 allele was associated with atopy or asthma. Methods: A total of 118 children with asthma, 145 children with non-asthmatic, but allergic phenotype, and 303 children without allergic or asthmatic disorders were studied. Results: There were no significant differences in the frequency of CCR5Δ32, or in the distributions of genotypes between the groups. The relative eosinophil blood count was slightly lower in patients with heterozygous genotype, than in patients with wild type genotype. Conclusion: No association was found between the susceptibility of allergy or asthma and the functional deficient CCR5Δ32 allele.