Painful nasal and oral lesions

Oral candidiasis, mucous membrane pemphigoid, pemphigus, erythema multiforme major, and Stevens-Johnson syndrome.7 The differentiating investigations are polymerase chain reaction test,38 Tzanck smear test, direct fluorescent antibody testing, and serological test for varicella zoster virus specific...

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Published inBMJ (Online) Vol. 371; p. m3778
Main Authors Chiang, Pin-Hsuan, Wang, Chi-Hui, Chen, Chun-Bing
Format Journal Article
LanguageEnglish
Published England BMJ Publishing Group LTD 25.11.2020
Subjects
Antiviral agents
Antiviral drugs
Biopsy
Candidiasis
Chicken pox
Conjunctivitis
Cooperation
Cornea
Denervation
Dermatology
Diagnosis, Differential
Erythema
Erythema multiforme
Eyelid
Giant cells
Herpes viruses
Herpes zoster
Herpes zoster ophthalmicus
Herpes Zoster Ophthalmicus - diagnosis
Herpes Zoster Ophthalmicus - pathology
Herpes Zoster Ophthalmicus - virology
Herpesvirus 3, Human
Humans
Immunosuppression
Immunosuppressive agents
Intravenous administration
Lesions
Male
Middle Aged
Mucosa
Nose
Nose - pathology
Nose - virology
Ophthalmic nerve
Palate - pathology
Palate - virology
Patients
Polymerase chain reaction
Retina
Retinitis
Skin Diseases, Vesiculobullous - diagnosis
Skin Diseases, Vesiculobullous - pathology
Skin Diseases, Vesiculobullous - virology
Skin Diseases, Viral - diagnosis
Skin Diseases, Viral - pathology
Skin Diseases, Viral - virology
Steroid hormones
Stevens-Johnson syndrome
Varicella
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Summary:Oral candidiasis, mucous membrane pemphigoid, pemphigus, erythema multiforme major, and Stevens-Johnson syndrome.7 The differentiating investigations are polymerase chain reaction test,38 Tzanck smear test, direct fluorescent antibody testing, and serological test for varicella zoster virus specific antibody.389 A positive Tzanck test result with multinucleated giant cells is not specific for varicella zoster virus or herpes zoster virus, but it is a low cost, quick test for herpes virus (positive rates: 60-90%).9 Consider biopsy for atypical mucocutaneous features, such as verrucous lesions.3 3. 10.1080/09273948.2017.1383447 29023181 6 Nithyanandam S Stephen J Joseph M Dabir S. Factors affecting visual outcome in herpes zoster ophthalmicus: a prospective study. 10.1128/JCM.06753-11 23035203 9 Ozcan A Senol M Saglam H. Comparison of the Tzanck test and polymerase chain reaction in the diagnosis of cutaneous herpes simplex and varicella zoster virus infections.
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ISSN:1756-1833
1756-1833
DOI:10.1136/bmj.m3778