The role of T helper 17 cell subsets in Sjögren's syndrome: similarities and differences between mouse model and humans

• Published in: Annals of the rheumatic diseases Vol. 73; no. 7; p. e43
• Main Authors: Lin, Xiang, Tian, Jie, Rui, Ke, Ma, Kong-Yang, Ko, King-Hung, Wang, Shengjun, Lu, Liwei
• Format: Journal Article
• Language: English
• Published: England BMJ Publishing Group LTD 01.07.2014
• Subjects: Female; Humans; Interleukin-17 - biosynthesis; Lymphocytes; Pathogenesis; Rodents; Salivary Glands - immunology; Sjogren's Syndrome - immunology; Studies; T cell receptors; T-Lymphocyte Subsets - immunology; Th17 Cells - immunology; Sjögren's Syndrome; T Cells; B cells; Autoimmune Diseases

[...]we revealed that IL-17 knockout (KO) mice were completely resistant for SS induction, while adoptive transfer of Th17 cells rapidly induced a full profile of SS in immunised IL-17 KO mice with markedly reduced saliva secretion, elevated autoantibody production and pronounced lymphocytic inflamm...