The role of T helper 17 cell subsets in Sjögren's syndrome: similarities and differences between mouse model and humans

[...]we revealed that IL-17 knockout (KO) mice were completely resistant for SS induction, while adoptive transfer of Th17 cells rapidly induced a full profile of SS in immunised IL-17 KO mice with markedly reduced saliva secretion, elevated autoantibody production and pronounced lymphocytic inflamm...

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Published inAnnals of the rheumatic diseases Vol. 73; no. 7; p. e43
Main Authors Lin, Xiang, Tian, Jie, Rui, Ke, Ma, Kong-Yang, Ko, King-Hung, Wang, Shengjun, Lu, Liwei
Format Journal Article
LanguageEnglish
Published England BMJ Publishing Group LTD 01.07.2014
Subjects
Female
Humans
Interleukin-17 - biosynthesis
Lymphocytes
Pathogenesis
Rodents
Salivary Glands - immunology
Sjogren's Syndrome - immunology
Studies
T cell receptors
T-Lymphocyte Subsets - immunology
Th17 Cells - immunology
Sjögren's Syndrome
T Cells
B cells
Autoimmune Diseases
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Summary:[...]we revealed that IL-17 knockout (KO) mice were completely resistant for SS induction, while adoptive transfer of Th17 cells rapidly induced a full profile of SS in immunised IL-17 KO mice with markedly reduced saliva secretion, elevated autoantibody production and pronounced lymphocytic inflammation and tissue damage in SG.
Bibliography:SourceType-Other Sources-1
content type line 63
ObjectType-Correspondence-1
ObjectType-Commentary-2
ObjectType-Article-3
ISSN:0003-4967
1468-2060
DOI:10.1136/annrheumdis-2014-205521