THE OESTROGENIC AND ANTIFERTILITY ACTIVITIES OF DIETHYLSTILBOESTROL AND DIMETHYLSTILBOESTROL IN RODENTS

ABSTRACT Median effective doses and relative potencies have been determined in vaginal smear tests in the rat and mouse for dimethylstilboestrol (DMS) and diethylstilboestrol (DES). These were done by injection or orally, and the relative potency of DMS in terms of DES varied from 0.0004 to 0.0165 a...

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Bibliographic Details
Published inActa endocrinologica (Copenhagen) Vol. 49; no. 1; pp. 83 - 89
Main Author EMMENS, C W
Format Journal Article
LanguageEnglish
Published Denmark 01.05.1965
Subjects
Animals
Diethylstilbestrol
Estradiol Congeners
Estrogens
Estrone
Female
Fertility
Injections, Subcutaneous
Mice
Pharmacology
Rats
Stilbenes
Vaginal Smears
ESTROGENS
INJECTIONS, SUBCUTANEOUS
PHARMACOLOGY
EXPERIMENTAL LAB STUDY
RATS
VAGINAL SMEARS
DIETHYLSTILBESTROL
MICE
FERTILITY
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Summary:ABSTRACT Median effective doses and relative potencies have been determined in vaginal smear tests in the rat and mouse for dimethylstilboestrol (DMS) and diethylstilboestrol (DES). These were done by injection or orally, and the relative potency of DMS in terms of DES varied from 0.0004 to 0.0165 according to species and route of administration. Comparison with the antifertility effects of these compounds in the same species by the same routes of administration lends support to the conclusion. also indicated in other studies, that in both cases the antifertility action is due to oestrogenic activity.
ISSN:0804-4643
0001-5598
1479-683X
DOI:10.1530/acta.0.0490083