Safety and immunogenicity of the Intradermal thai red cross (2-2-2-0-1-1) post exposure vaccination regimen in the Indian population using purified chick embryo cell rabies vaccine
PURPOSE: To test the immunogenicity of the WHO recommended "2-2-2-0-1-1" post-exposure rabies vaccination regimen in Indian subjects to determine the feasibility of replacing crude sheep brain nerve tissue rabies vaccine with modern tissue culture rabies vaccine at major anti-rabies treatm...
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Published in | Indian journal of medical microbiology Vol. 23; no. 1; pp. 24 - 28 |
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Main Author | |
Format | Journal Article |
Language | English |
Published |
India
Medknow Publications on behalf of Indian Association of Medical Microbiology
01.01.2005
Elsevier B.V |
Subjects | |
Online Access | Get full text |
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Summary: | PURPOSE: To test the immunogenicity of the WHO recommended
"2-2-2-0-1-1" post-exposure rabies vaccination regimen in Indian
subjects to determine the feasibility of replacing crude sheep brain
nerve tissue rabies vaccine with modern tissue culture rabies vaccine
at major anti-rabies treatment centers throughout India. METHODS:
Purified chick embryo cell vaccine (PCECV) was administered in the
dosage of 0.1mL per site to 53 Indian subjects. RESULTS: All subjects
produced rabies antibodies above 0.5IU/mL by day 14 post-vaccination.
Only minor adverse reactions including swelling (6.6%), erythema (5.4%)
and pain (1.4%) were observed for which no treatment was required.
CONCLUSIONS: This study demonstrated that PCECV is safe and highly
immunogenic in Indian subjects when administered intradermally as
0.1mL/site using the "2-2-2-0-1-1" post-exposure regimen. |
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Bibliography: | ObjectType-Article-1 SourceType-Scholarly Journals-1 ObjectType-Feature-2 content type line 23 |
ISSN: | 0255-0857 |
DOI: | 10.1016/S0255-0857(21)02707-9 |