SARS-CoV-2 infection severity is linked to superior humoral immunity against the spike

• Published in: bioRxiv
• Main Authors: Guthmiller, Jenna J, Stovicek, Olivia, Wang, Jiaolong, Changrob, Siriruk, Li, Lei, Halfmann, Peter, Zheng, Nai-Ying, Utset, Henry, Stamper, Christopher T, Dugan, Haley L, Miller, William D, Huang, Min, Dai, Ya-Nan, Nelson, Christopher A, Hall, Paige D, Jansen, Maud, Shanmugarajah, Kumaran, Donington, Jessica S, Krammer, Florian, Fremont, Daved H, Joachimiak, Andrzej, Kawaoka, Yoshihiro, Tesic, Vera, Madariaga, Maria Lucia, Wilson, Patrick C
• Format: Journal Article Paper
• Language: English
• Published: United States Cold Spring Harbor Laboratory Press 13.09.2020; Cold Spring Harbor Laboratory
• Edition: 1.1
• Subjects: Antibodies; Antibody response; Antigens; Coronaviruses; Epitopes; Humoral immunity; Immunological memory; Immunology; Infections; Nucleocapsids; Pandemics; Proteins; Severe acute respiratory syndrome coronavirus 2; Structural proteins

Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) is currently causing a global pandemic. The antigen specificity and kinetics of the antibody response mounted against this novel virus are not understood in detail. Here, we report that subjects with a more severe SARS-CoV-2 infection exhi...