Increases in the oxytocin-induced prostaglandin F2 alpha response and reduction in the concentrations of endometrial oxytocin receptors in ewes in response to progesterone

Ovariectomized ewes were given progesterone and oestrogen priming as steroid pretreatment and subsequently treated with progesterone, prostaglandin F 2α (PGF 2α ), or both. In Expt 1, plasma concentrations of the metabolite 13,14-dihydro-15-keto-PGF 2α (PGFM) were measured after an i.v. injection of...

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Bibliographic Details
Published inJournal of reproduction & fertility Vol. 95; no. 1; pp. 11 - 18
Main Authors Lau, T.M, Gow, C.B, Fairclough, R.J
Format Journal Article
LanguageEnglish
Published England Society for Reproduction and Fertility 01.05.1992
Subjects
Animals
Dinoprost - analogs & derivatives
Dinoprost - biosynthesis
Dinoprost - blood
Dinoprost - pharmacology
endometrium
Endometrium - drug effects
Endometrium - metabolism
estrogens
Estrogens - pharmacology
ewes
Female
hormone receptors
metabolites
ovariectomized females
Ovariectomy
oxytocin
Oxytocin - pharmacology
progesterone
Progesterone - pharmacology
prostaglandins
Receptors, Angiotensin - metabolism
Receptors, Oxytocin
Sheep - blood
Sheep - metabolism
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Summary:Ovariectomized ewes were given progesterone and oestrogen priming as steroid pretreatment and subsequently treated with progesterone, prostaglandin F 2α (PGF 2α ), or both. In Expt 1, plasma concentrations of the metabolite 13,14-dihydro-15-keto-PGF 2α (PGFM) were measured after an i.v. injection of oxytocin. There was little PGFM response in the untreated control ewes or in the pretreated ewes. Treatment with PGF 2α alone had no effect ( P > 0·05), whereas treatment with progesterone either alone or with PGF 2α significantly ( P < 0·05) increased the uterine PGFM response to oxytocin. In Expt 2, chronically ovariectomized ewes had high concentrations of endometrial oxytocin receptors. Treatment with PGF 2α alone did not alter the concentrations of the receptors. Treatment with progesterone either alone or with PGF 2α significantly ( P < 0·05) reduced the concentrations of the receptors. It is concluded that progesterone promotes the PGFM response to oxytocin, but simultaneously suppresses the concentrations of endometrial oxytocin receptors. Keywords: progesterone; PGF 2α ; PGFM; oxytocin; receptor; uterus; sheep
ISSN:0022-4251
1470-1626
1741-7899
DOI:10.1530/jrf.0.0950011