STUDIES ON A NON-MELATONIN PINEAL ANTI-GONADOTROPHIN

ABSTRACT Continuing investigation of pineal gland function indicates that the anti-gonadotrophic activity of this organ cannot be attributed solely to the postulated hormone melatonin, the concentration of which is negligible in the pineal body compared to quantities required to produce unequivocal...

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Bibliographic Details
Published inActa endocrinologica (Copenhagen) Vol. 69; no. 2; pp. 257 - 266
Main Authors Benson, B, Matthews, M J, Rodin, A E
Format Journal Article
LanguageEnglish
Published Denmark 01.02.1972
Subjects
Animals
Biological Assay
Castration
Cattle
Chromatography
Chromatography, Gel
Female
Filtration
Gonadotropins - antagonists & inhibitors
Male
Melatonin - pharmacology
Organ Size
Ovary - drug effects
Ovary - physiology
Pineal Gland - analysis
Rats
Tissue Extracts - analysis
Tissue Extracts - isolation & purification
Tissue Extracts - pharmacology
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Summary:ABSTRACT Continuing investigation of pineal gland function indicates that the anti-gonadotrophic activity of this organ cannot be attributed solely to the postulated hormone melatonin, the concentration of which is negligible in the pineal body compared to quantities required to produce unequivocal physiological effects. A non-melatonin antigonadotrophic substance recently isolated from bovine pineal glands was further purified by organic solvent extraction, ultrafiltration and gel filtration. Studies of partial blockage of compensatory ovarian hypertrophy in unilaterally ovariectomized Charles River CD-1 mice indicated that this substance is significantly more potent than melatonin in this test system.
ISSN:0804-4643
0001-5598
1479-683X
DOI:10.1530/acta.0.0690257