COMPARISON OF EFFECTS OF C19 (ANDROSTENE OR ANDROSTANE) STEROIDS ON SERUM GONADOTROPHIN CONCENTRATIONS AND ON ACCESSORY REPRODUCTIVE ORGAN WEIGHTS IN GONADECTOMIZED, ADULT MALE RATS

• Published in: Acta endocrinologica (Copenhagen) Vol. 84; no. 4; pp. 829 - 841
• Main Authors: Verjans, H L, Eik-Nes, K B
• Format: Journal Article
• Language: English
• Published: Denmark 01.04.1977
• Subjects: Androstane-3,17-diol - administration & dosage; Androstane-3,17-diol - pharmacology; Androstanes - pharmacology; Androstenedione - pharmacology; Animals; Castration; Dihydrotestosterone - administration & dosage; Dihydrotestosterone - pharmacology; Dose-Response Relationship, Drug; Follicle Stimulating Hormone - blood; Luteinizing Hormone - blood; Male; Organ Size - drug effects; Prostate - drug effects; Rats; Seminal Vesicles - drug effects; TESTES; Testosterone - blood
• ISSN: 0804-4643; 0001-5598; 1479-683X
• DOI: 10.1530/acta.0.0840829

ABSTRACT The effect of subcutaneous administration of graded doses of C19 (androstene or androstane) steroids on serum levels of LH and FSH and on weights of accessory reproductive organs in gonadectomized, adult male rats were investigated. The C19 steroids were administered during 7 days in doses of 100, 50, 25, 12.5 or 6.25 μg per 100 g body weight per day. With the amounts of steroids used, 5α-dihydrotestosterone and 5α-androstane-3α,17β-diol had a high potency in preventing the rise of serum gonadotrophin concentrations and in curbing the decrease of weights of ventral prostates and seminal vesicles following orchidectomy. 5α-Androstane-3β,17β-diol showed no such effects. Positive feedback effects on serum gonadotrophins in castrates were observed following injection of certain doses of some steroids. Effects of steroids on accessory reproductive organs did not always correlate with those on gonadotrophic function of the hypothalamic-pituitary unit.