1,2,4-Triazole-conjugated Fluoroquinolones as Potential Candidates for New Antibacterial Agents

In this study, synthesis of 1,2,4 triazole-fluoroquinolone hybrid compounds was realized. 7a-d hybrid compound was obtained as a result of mannich reaction with 6a-b triazole compounds norfloxacin and ciprofloxacin. 1H-NMR, 13C-NMR, Mass Spectrometry and Elemental Analysis confirmed the structures o...

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Bibliographic Details
Published inLetters in organic chemistry Vol. 21; no. 8; pp. 669 - 676
Main Authors Cebeci, Yildiz Uygun, Karaoglu, Senguel Alpay
Format Journal Article
LanguageEnglish
Published SHARJAH Bentham Science Publ Ltd 01.01.2024
Subjects
Chemistry
Chemistry, Organic
Physical Sciences
Science & Technology
Fluoroquinolones
ALDOL
DESIGN
SCHIFF
schiff base
QUINOLONES
ORGANOCATALYSIS
antibacterial
triazole
hybride molecule
ANTICANCER
ANTIMICROBIAL EVALUATION
CHEMISTRY
mannich base
DERIVATIVES
MANNICH-BASES
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Summary:In this study, synthesis of 1,2,4 triazole-fluoroquinolone hybrid compounds was realized. 7a-d hybrid compound was obtained as a result of mannich reaction with 6a-b triazole compounds norfloxacin and ciprofloxacin. 1H-NMR, 13C-NMR, Mass Spectrometry and Elemental Analysis confirmed the structures of all synthesized compounds. The antimicrobial activities of all compounds were investigated, and it was observed that 7a-d compounds, which are mannich bases, showed excellent activity.
ISSN:1570-1786
1875-6255
DOI:10.2174/0115701786270260231215101046