PO-087 The WCRF/AICR third expert report on diet, nutrition, physical activity and cancer: updated recommendations

• Published in: ESMO open Vol. 3; no. Suppl 2; p. A260
• Main Authors: Kampman, E, Thompson, RL, Wiseman, MJ, Mitrou, G, Allen, K
• Format: Journal Article
• Language: English
• Published: Elsevier Ltd 01.07.2018
• ISSN: 2059-7029; 2059-7029
• DOI: 10.1136/esmoopen-2018-EACR25.615

IntroductionCancer causes one in eight deaths worldwide and is rapidly becoming a global pandemic. Diet, nutrition and physical activity play a key role in the prevention of cancer and other non-communicable diseases (NCDs). Evidence-based recommendations are necessary to help people make informed lifestyle choices in their daily lives to reduce their cancer risk. This talk will present the main global findings from World Cancer Research Fund (WCRF)/American Institute for Cancer Research (AICR) Third Expert Report (2018) on Diet, Nutrition, Physical Activity and Cancer which was built upon the WCRF/AICR Second Expert Report (2007), including the updated Cancer Prevention Recommendations and will suggest future research directions.Material and methodsThe Third Expert Report brings together the very latest research from the Continuous Update Project’s (CUP) rigorous systematic review of the accumulated best available, scientific and worldwide evidence on cancer prevention and survival related to diet, nutrition and physical activity. The Recommendations are derived from the evidence of 18 systematic literature reviews and a review of evidence on energy balance and body fatness, supported by expert reviews on the experimental evidence from human and animal studies that could plausibly explain a causal link between an exposure and cancer. A Panel of independent international experts assessed and judged the body of evidence, drew conclusions and made recommendations for a global audience, taking into account regional and special circumstances.Results and discussionsThis talk will present the latest evidence on the links between body fatness, physical activity and cancer risk highlighting the updated relevant Recommendations. Additionally, associations of cancer risk with consumption of specific foods such as wholegrains, vegetables, processed foods, red meat, sugar sweetened drinks and alcohol will be also presented. Finally, this talk will touch upon the latest evidence linking cancer risk to lifecourse exposures and will suggest future research priorities.ConclusionAs evidence accrues, conclusions regarding the relation of diet, nutrition, physical activity to cancer are mostly strengthened to before, though with some change in emphasis. A number of future research directions have been identified including a better understanding of the mechanistic links of lifecourse factors to cancer and more global representative research on specific exposures in relation to cancer.