Ventricular hypertrophy in a young weightlifter
Genetic analysis excluded sarcomere protein gene mutations as well as other genetic causes of cardiomyopathy including metabolic diseases and neuromuscular disorders. Athlete’s heart Anabolic steroid-induced cardiomyopathy Hypertensive cardiomyopathy Cardiac amyloidosis Answer: B Although mutations...
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Published in | Heart (British Cardiac Society) Vol. 110; no. 3; pp. 194 - 220 |
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Main Authors | , , |
Format | Journal Article |
Language | English |
Published |
England
BMJ Publishing Group Ltd and British Cardiovascular Society
01.02.2024
BMJ Publishing Group LTD |
Subjects | |
Online Access | Get full text |
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Summary: | Genetic analysis excluded sarcomere protein gene mutations as well as other genetic causes of cardiomyopathy including metabolic diseases and neuromuscular disorders. Athlete’s heart Anabolic steroid-induced cardiomyopathy Hypertensive cardiomyopathy Cardiac amyloidosis Answer: B Although mutations in the sarcomere protein genes are often the cause of hypertrophic cardiomyopathy (HCM),1 acquired aetiologies such as chronic drug exposure can cause inappropriate left ventricular structural changes.2 Anabolic-androgenic steroids (AASs) are synthetic derivatives that mimic the effects of male hormone testosterone and are used as performance-enhancing drugs. The use of doping drugs has been linked to increasing risk of sudden cardiac death and ventricular arrhythmias with exercise.5 Thus, late gadolinium-enhanced cardiac magnetic resonance has increasingly proven its role in risk stratification of patients with HCM, especially as fibrosis may constitute the underlying arrhythmogenic substrate5 (figure 2). |
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Bibliography: | ObjectType-Article-1 SourceType-Scholarly Journals-1 ObjectType-Feature-2 content type line 23 |
ISSN: | 1355-6037 1468-201X |
DOI: | 10.1136/heartjnl-2023-323413 |