Post-menopausal concentrations of plasma oestradiol, oestrone, FSH and LH and of total urinary oestradiol and oestrone after a single sublingual dose of oestradiol-17β

We report the effects of sublingual absorption of a single dose (0.5 mg) of oestradiol-17β (E2) in 8 post-menopausal women, on plasma E2 and oestrone (E1), urine elimination of total E2 + E1 and on plasma FSH and LH. The results show that sublingual absorption of E2 occurs and that plasma concentrat...

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Published inActa endocrinologica (Copenhagen) Vol. 101; no. 1; pp. 93 - 97
Main Authors Fiet, J, Hermano, M, Witte, J, Villette, J M, Haimart, M, Gourmel, B, Tabuteau, F, Rouffy, J, Dreux, C
Format Journal Article
LanguageEnglish
Published Denmark 01.09.1982
Subjects
Absorption
Aged
Estradiol - blood
Estradiol - pharmacology
Estradiol - urine
Estrone - blood
Estrone - urine
Female
Follicle Stimulating Hormone - blood
Humans
Luteinizing Hormone - blood
Menopause
Middle Aged
Ovaries
Radioimmunoassay
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Summary:We report the effects of sublingual absorption of a single dose (0.5 mg) of oestradiol-17β (E2) in 8 post-menopausal women, on plasma E2 and oestrone (E1), urine elimination of total E2 + E1 and on plasma FSH and LH. The results show that sublingual absorption of E2 occurs and that plasma concentrations of E2 obtained (between 133.2 to 320 pmol/1) in this way were higher than those obtained after percutaneous absorption of a single dose (3 mg)of E2. The ratio E1/E2 in plasma is close to that of pre-menopausal women.
ISSN:0804-4643
0001-5598
1479-683X
DOI:10.1530/acta.0.1010093