COMPARATIVE STUDIES OF THE POTENTIATION OF CORTICOTROPHIN ACTIVITY BY SEVERAL INACTIVE DERIVATIVES

ABSTRACT A number of corticotrophin analogues have been prepared, some of which potentiate the biological activity of the untreated hormone in vitro. The free amino groups of corticotrophin appear to be essential not only for hormonal activity, but also for the interaction of the analogues with the...

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Bibliographic Details
Published inEuropean journal of endocrinology Vol. 42; no. 2; pp. 209 - 213
Main Authors Cohen, Arthur I., Frieden, Edward H.
Format Journal Article
LanguageEnglish
Published 01.02.1963
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Summary:ABSTRACT A number of corticotrophin analogues have been prepared, some of which potentiate the biological activity of the untreated hormone in vitro. The free amino groups of corticotrophin appear to be essential not only for hormonal activity, but also for the interaction of the analogues with the tissue corticotrophin inactivating system which is assumed to account for the potentiating effect.
ISSN:0804-4643
1479-683X
DOI:10.1530/acta.0.0420209