Investigation of Reported Anaphylaxis Post COVID-19 Vaccination in Subjects with History of Allergies and Anaphylaxis

Background: Two mRNA COVID-19 vaccines, Pfizer-BioNTech and Moderna, are currently approved in the United States, and one viral-vector vaccine, J&J/Janssen, is authorized for limited use. The Vaccine Adverse Event Reporting System (VAERS) database gathers reports of adverse effects, including an...

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Bibliographic Details
Published inCoronaviruses Vol. 4; no. 3
Main Authors Desai, Aditya P., Desai, Aryan P., Ochs, Victoria S., Desai, Prashant V.
Format Journal Article
LanguageEnglish
Published Bentham Science Publishers 2023
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Summary:Background: Two mRNA COVID-19 vaccines, Pfizer-BioNTech and Moderna, are currently approved in the United States, and one viral-vector vaccine, J&J/Janssen, is authorized for limited use. The Vaccine Adverse Event Reporting System (VAERS) database gathers reports of adverse effects, including anaphylaxis. Objective: In this manuscript, we provide a summary of reported incidence of anaphylaxis rates following administration of the two mRNA and one viral-vector COVID-19 vaccine. Methods: A detailed investigation of the relative risk of anaphylaxis for recipients with or without a prior history of allergy and/or anaphylaxis is also described. Results: Overall reported incidence of anaphylaxis is 4.49 [95% CI: 0.25 – 8.73] cases per million doses administered. Conclusion: The reported risk of anaphylaxis is 1.83 times greater for recipients with prior allergies and no anaphylaxis but 17.70 times greater for recipients with prior allergies and anaphylaxis.
ISSN:2666-7967
DOI:10.2174/2666796704666230904150831