Population genetic studies in the genomic sequencing era

Recent advances in high-throughput sequencing technologies have revolutionized the field of population genetics. Data now routinely contain genomic level polymorphism information, and the low cost of DNA sequencing enables researchers to investigate tens of thousands of subjects at a time. This prov...

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Bibliographic Details
Published inDōngwùxué yánjiū Vol. 36; no. 4; pp. 223 - 232
Main Author Chen, Hua
Format Journal Article
LanguageChinese
English
Published China Kunming Institute of Zoology, The Chinese Academy of Sciences 18.07.2015
Subjects
Animals
Deoxyribonucleic acid
DNA
Gene Frequency
Genetics
Genetics, Population
Genomics
Haplotypes
High-Throughput Nucleotide Sequencing
Humans
Linkage Disequilibrium
Population
Population genetics
Population studies
Selection, Genetic
Studies
Technology
基因测序
基因组测序
测序技术
研究人员
种群遗传学
群体遗传学
自然选择
遗传理论
China
Allele frequency spectrum
Demography
Population genetic inference
Linkage disequilibrium
Natural selection
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Summary:Recent advances in high-throughput sequencing technologies have revolutionized the field of population genetics. Data now routinely contain genomic level polymorphism information, and the low cost of DNA sequencing enables researchers to investigate tens of thousands of subjects at a time. This provides an unprecedented opportunity to address fundamental evolutionary questions, while posing challenges on traditional population genetic theories and methods. This review provides an overview of the recent methodological developments in the field of population genetics, specifically methods used to infer ancient population history and investigate natural selection using large-sample, large-scale genetic data. Several open questions are also discussed at the end of the review.
Bibliography:Population genetic inference; Allelefrequency spectrum; Linkage disequilibrium; Naturalselection; Demography
53-1040/Q
Recent advances in high-throughput sequencing technologies have revolutionized the field of population genetics. Data now routinely contain genomic level polymorphism information, and the low cost of DNA sequencing enables researchers to investigate tens of thousands of subjects at a time. This provides an unprecedented opportunity to address fundamental evolutionary questions, while posing challenges on traditional population genetic theories and methods. This review provides an overview of the recent methodological developments in the field of population genetics, specifically methods used to infer ancient population history and investigate natural selection using large-sample, large-scale genetic data. Several open questions are also discussed at the end of the review.
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ISSN:0254-5853
DOI:10.13918/j.issn.2095-8137.2015.4.223