P2-118 Vitamin C intake from diary recordings and risk of breast cancer in the UK dietary cohort consortium

• Published in: Journal of epidemiology and community health (1979) Vol. 65; no. Suppl 1; p. A253
• Main Authors: Hutchinson, J, Lentjes, M, Greenwood, D, Burley, V, Cade, J, Cleghorn, C, Threapleton, D, Key, T, Cairns, B, Keogh, R, Dahm, C, Brunner, E, Shipley, M, Kuh, D, Mishra, G, Stephen, A, Bhaniani, A, Borgulya, G, Khaw, K T, Rodwell, S
• Format: Journal Article
• Language: English
• Published: London BMJ Publishing Group Ltd 01.08.2011; BMJ Publishing Group LTD
• Subjects: Breast cancer; Cancer; Case studies; Diets; Health risks; Vitamins; British Isles
• ISSN: 0143-005X; 1470-2738
• DOI: 10.1136/jech.2011.142976i.53

IntroductionVitamin C intake has been inversely associated with breast cancer risk in case-control studies, but not in meta-analyses of cohort studies using Food Frequency Questionnaires. No study has assessed this relationship prospectively using food diaries which may more accurately measure intake.MethodsEstimated dietary vitamin C intake was derived from 4 to 7 day food diaries pooled from five prospective studies in the UK Dietary Cohort Consortium. This nested case-control study of 851 incident breast cancer cases and 2727 matched controls examined breast cancer risk in relation to dietary vitamin C intake using conditional logistic regression adjusting for relevant covariates. Additionally, total vitamin C intake from supplements and diet was analysed in the three largest cohorts.ResultsNo evidence of an association was observed between breast cancer risk and dietary (OR=1.00 per 60 mg/d, 95% CI 0.91 to 1.09, Ptrend=1.0) or total vitamin C intake (OR=1.01 per 60 mg/d, 95% CI 1.00 to 1.03, Ptrend=0.1) in analyses using continuous estimates or by fifths of intake. Additionally, there was no association for post-menopausal women.ConclusionsThis pooled analysis of individual UK women found no evidence of associations between breast cancer incidence and dietary or total vitamin C intake derived uniquely from detailed diary recordings.