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By contrast, SFB depletion led to reduced IL-17A and lessened liver damage. [...]obesity-induced alterations to the gut microbiome may play a critical role in the up-regulation of cytokines, such as IL-17A leading to enhanced hepatic inflammation and NAFLD progression. [...]a higher proportion of th...

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Bibliographic Details
Published inGut Vol. 63; no. 9; pp. 1522 - 1523
Main Author McLean, Mairi H
Format Journal Article
LanguageEnglish
Published London BMJ Publishing Group LTD 01.09.2014
Subjects
Gastroenterology
Hepatology
Liver cirrhosis
Liver diseases
Mutation
Obesity
Rodents
Stem cells
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Summary:By contrast, SFB depletion led to reduced IL-17A and lessened liver damage. [...]obesity-induced alterations to the gut microbiome may play a critical role in the up-regulation of cytokines, such as IL-17A leading to enhanced hepatic inflammation and NAFLD progression. [...]a higher proportion of those taking NSBB with SBP developed hepatorenal syndrome (HRS) (24% vs 11%) and acute kidney injury (20% vs 8%), than those who were not on these drugs.
Bibliography:ObjectType-Article-1
SourceType-Scholarly Journals-1
ObjectType-Feature-2
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ISSN:0017-5749
1468-3288
DOI:10.1136/gutjnl-2014-307930