Mean platelet volume (MPV) as independent predictor of microvascular disease in diabetes mellitus

• Main Author: Babulal, Meena
• Format: Web Resource
• Language: English
• Published: Morressier 01.01.2017
• DOI: 10.26226/morressier.59d51847d462b80296ca3cc0

Background: Microvascular disease is the leading cause of disability and premature mortality in patients with diabetes. The risk of coronary heart disease (CHD), stroke, and peripheral arterial disease (PAD) in diabetic patients increased two to four-fold. Platelets contribute to the majority of these events by playing a key role in the development of atherothrombosis. Recently, elevated mean platelet volume (MPV) is accepted as an indicator of platelet activation and indirectly, as a simple and time-saving marker of increased microvascular disease risk. Aim: The present study aims to investigate whether MPV behave as a forerunner to the prediction of microvascular disease risk in diabetics. Methods: A total of 100 diabetics (both type-1 and type-2 diabetes) and 100 age and gender-matched healthy subjects were enrolled justifying ADA criteria and relevant exclusion criteria. Anthropometric indices, biochemical and clinical parameters were measured. Diabetics were further divided into three groups according to HBA1C for glucometabolic status as excellent, good and poor glucometabolic status with group A HBA1c u22646.5%, Group B >6.5 but u22648% and Group C >8% constituting 12, 42 and 46 patients respectively. The mean platelet volume (MPV), platelet count, and other blood cell indices were measured using an automated Beckman Coulter haemo analyser. Receiver operating characteristic, partial correlation and logistic regression analyses were employed for evaluation. Results: In the present study, males accounted for 62% (n=26) and female for 38% (n=38). The mean age for 3 groups was 40.50 u00b1 5.08, 42.26 u00b1 6.42 and 44.56u00b1 8.25years respectively. MPV was found to be highly statistically significant among both T1 and T2DM when compared to controls (9.606u00b11.03 and 8.968u00b11.23 vs 7.85u00b1 0.680, p =0.0001).Similarly, MPV also showed statistically significant correlation when compared to HbA1C in both T1 (p=0.006 r-0.4968) and T2 (p=0.013, r- 0.316) diabetics. Conclusion: In our present study, MPV of diabetics (both type1 and type2) was significantly higher than control subjects. Similarly, MPV was significantly higher in patients with high HBA1C levels i.e. with poor glycemic control. These data suggests that MPV has a potential role in platelet activity measurement in diabetes. Though another method for platelet function is available but they are time-consuming and expensive. MPV determination is widely available, at low cost, does not require special training, so in developing countries like India where expensive investigations are not in reach of common man MPV determination can be done, as it is a simple parameter to assess the vascular events in diabetics.