1176 Incidence and Organisam Pattern in Early Onset Neonatal Sepsis

• Published in: Archives of disease in childhood Vol. 97; no. Suppl 2; p. A337
• Main Authors: Avramovic, LZ Hajnal, Mitrovic, TP Lazic, Rascanin, M, Korac, J, Curkovic, A
• Format: Journal Article
• Language: English
• Published: London BMJ Publishing Group Ltd and Royal College of Paediatrics and Child Health 01.10.2012; BMJ Publishing Group LTD
• Subjects: Antibiotics; E coli; Infants; Neonates; Prevention; Prophylaxis; Young Children
• ISSN: 0003-9888; 1468-2044
• DOI: 10.1136/archdischild-2012-302724.1176

Background and Aim Early onset neonatal sepsis (EONS) occurs within the first 3 to 7 days of life. The incidence of EONS vary from 1 to 4.6 cases per 1000 live newborns. The distributions of organisms in EONS helps to use appropriate antibiotics prophylaxis during labour and neonates with suspected sepsis. The aim of our study was to compare the incidence and the organisms distribution for EONS during 2009, 2010 and 2011 for infants admitted to NICU in our Neonatal Department. Methods Data were retrieved from newborns with positive bacterial blood and/or cerebral spinal fluid in the first 72 h after birth. We compared incidence rate and causative organisms. Results A total of 198 newborns with suspected sepsis, 125 had positive cultures over the time of three years period. The EONS incidence was 8.1 (54 per 6659 neonates) in 2009, 5.7 (40 per 6994 neonates) in 2010. and 4.5 (31 per 6883 neonates) in 2011. B Streptococcus were the most common organism (3.4/1000) in the term infants. Staphylococcus coagulase-negative was second with rate 2.8/1000. Escherichia coli (3.8/1000) and Staphylococcus coagulase-negative (3.5/1000) were the most common in preterm infants. There were no significant changes in organism pattern in EONS during study period. Conclusion The rate of EONS among neonates in NICU in study period was not significantly changed and we did not find significant change in bacterial organisms. So, we suggest further prevention of EONS focused on prevention of vertical transmission and intrapartum antibiotics prophylaxis.