Computational strategies for the development of novel small molecule rheumatoid arthritis therapies

Rheumatoid arthritis is a chronic autoimmune disorder that causes joint disfigurement and destruction leading to reduced quality of life. Effective drug therapies include the Disease Modifying Anti-Rheumatic Drugs which can help impede the progression of the disease but are not always effective. It...

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Bibliographic Details
Published inAnti-inflammatory & anti-allergy agents in medicinal chemistry Vol. 10; no. 2; p. 85
Main Authors Mahfouz, Tarek M, Kinder, David H
Format Journal Article
LanguageEnglish
Published United Arab Emirates 2011
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Summary:Rheumatoid arthritis is a chronic autoimmune disorder that causes joint disfigurement and destruction leading to reduced quality of life. Effective drug therapies include the Disease Modifying Anti-Rheumatic Drugs which can help impede the progression of the disease but are not always effective. It is, therefore important to identify novel and effective therapies to combat this debilitating disorder. Several bioinformatics tools and computational approaches can be utilized to identify novel and effective therapies for rheumatoid arthritis and these are presented here.
ISSN:1871-5230
DOI:10.2174/187152111795508306