Bead-Based Flow-Cytometry in Medical Microbiological Research and Diagnosis

Bead-based flow cytometry (xMAP® and xTAG® Technology, Luminex Corporation) is a recently developed technology that allows for simultaneous quantification of multiple antibodies, antigens or oligonucleotides in a single sample. The newest generation of analyzers allow multiplexing of up to 500 uniqu...

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Bibliographic Details
Published inThe Role of New Technologies in Medical Microbiological Research and Diagnosis Vol. 1; no. 1; pp. 151 - 160
Main Authors Verkaik, N.J, de Vogel, C.P, J.B. van W, W, van Belkum, A
Format Book Chapter
LanguageEnglish
Published 01.01.2012
Subjects
Bead-based
Flow Cytometry
Luminex
XMap
Median Intensity Fluorescence
Immunity
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Summary:Bead-based flow cytometry (xMAP® and xTAG® Technology, Luminex Corporation) is a recently developed technology that allows for simultaneous quantification of multiple antibodies, antigens or oligonucleotides in a single sample. The newest generation of analyzers allow multiplexing of up to 500 unique tests within a single sample, which renders this technique much less timeconsuming than conventional testing methodsologies. Numerous applications have already been developed for this technology in both medical microbiological research and diagnosis, with the number of reported applications still growing rapidly. Bead-based flow-cytometry has already firmly established itself as a supplemental and/or alternative technology to the more traditional routine diagnostic and research microbiology test platforms.
DOI:10.2174/978160805316211201010151