In vitro interaction between caffeine and some penicillin antibiotics against Staphylococcus aureus
Purpose: The aim of this study is to evaluate the in vitro interaction of some penicillins (amoxicillin, ampicillin and benzylpenicillin) and caffeine against . Method: The interaction between the penicillins and caffeine was studied using the Overlay Inoculum Susceptibility Disc (OLISD) method. M...
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Published in | Tropical journal of pharmaceutical research Vol. 7; no. 2 |
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Main Authors | , , , |
Format | Journal Article |
Language | English |
Published |
Nigeria
Pharmacotherapy Group, Faculty of Pharmacy, University of Benin, Benin City, Nigeria
01.12.2008
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Subjects | |
Online Access | Get full text |
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Summary: | Purpose: The aim of this study is to evaluate the in vitro
interaction of some penicillins (amoxicillin, ampicillin and
benzylpenicillin) and caffeine against . Method: The
interaction between the penicillins and caffeine was studied using the
Overlay Inoculum Susceptibility Disc (OLISD) method. Minimum inhibitory
concentrations (MIC) of the drugs were determined separately and in
combination with caffeine (5 and 10 mg/ml). Result: At 5 and 10
mg/ml, caffeine decreased the MIC of amoxicillin by 22 and 25 times
respectively, while that of ampicillin was decreased by 6 and 8 times.
The MIC of benzylpenicillin against Staphylococcus aureus was, however,
increased by 59 and 40 times at caffeine concentrations of 5 and 10
mg/ml respectively. The inhibition zone diameter increment above 19 %
(index of synergism in OLISD method) was recorded only for amoxicillin
at amoxicillin concentrations of 7.81, 15.3, 31.25 and 62.5 mg/ml.
Conclusion: The results of this study revealed that the concomitant
use of caffeine and the studied antibiotics may potentiate the
antibacterial effect of amoxicillin against Staphylococcus aureus,
decrease that of benzylpenicillin and has virtually no effect on that
of ampicillin. This implies that the intake of caffeine in form of
analgesic combination or as tea, coffee, beverages or from other food
sources may affect the effectiveness of a co - administered amoxicillin
and bezylpenicillin. |
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ISSN: | 1596-5996 1596-5996 1596-9827 |
DOI: | 10.4314/tjpr.v7i2.14675 |