Evaluation of Pharmaceutical and Microbial Qualities of Some Herbal Medicinal Products in South Western Nigeria
Purpose: The aim of the present study was to investigate the pharmaceutical and microbial qualities of 21 different (of various dosage forms) Herbal Medicinal Products (HMPs) sourced from some traditional medicine sales outlets and retail pharmacy outlets in south western Nigeria. Method: The pharma...
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Published in | Tropical journal of pharmaceutical research Vol. 6; no. 1 |
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Main Authors | , , |
Format | Journal Article |
Language | English |
Published |
Nigeria
Pharmacotherapy Group, Faculty of Pharmacy, University of Benin, Benin City, Nigeria
31.07.2007
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Subjects | |
Online Access | Get full text |
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Summary: | Purpose: The aim of the present study was to investigate the
pharmaceutical and microbial qualities of 21 different (of various
dosage forms) Herbal Medicinal Products (HMPs) sourced from some
traditional medicine sales outlets and retail pharmacy outlets in south
western Nigeria. Method: The pharmaceutical qualities evaluated
include tablet crushing strength, friability, disintegration time;
density of the solutions and suspensions; particle size and angle of
repose of the powders. Phytochemical tests were carried out to assess
the class of compounds present in the formulations and the microbial
quality of the products was also evaluated. Results: The results show
that twelve (57.1%) of the products had their manufacturing and expiry
dates stated, nine (42.9%) products have been registered by NAFDAC and
ten (47.6%) did not have their content stated but had their therapeutic
claims indicated on the container. The tablet formulation (Product A)
showed acceptable crushing strength and friability but failed the test
for disintegration time. The angle of repose of the powder dosage forms
were considerably high showing that the powders were highly cohesive
and not free flowing. The microbial load of the products varied
considerably. Ten (47.6%) of the samples were contaminated by E. coli,
seven (33%) were contaminated by Salmonella, fifteen (71.4%) were
contaminated by Staphylococcus aureus and twelve (57.1%) were
contaminated by fungi. Conclusion: There is need for constant
monitoring and control of the standards of herbal medicines available
in the Nigerian market. |
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ISSN: | 1596-5996 1596-5996 1596-9827 |
DOI: | 10.4314/tjpr.v6i1.14644 |