Incorporation of Certain Hydrophobic Excipients in the Core of Melt Granules of Paracetamol and the Effect on Drug Release Profiles
Objective - A process of melt granulation whereby the drug powder is mixed with a melted wax has been used to modify the dissolution rates of drug particles. The present study investigated how the incorporation of hydrophobic materials (talc or magnesium stearate) in the core of such granules may fu...
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Published in | Tropical journal of pharmaceutical research Vol. 6; no. 3 |
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Main Authors | , , , , |
Format | Journal Article |
Language | English |
Published |
Nigeria
Pharmacotherapy Group, Faculty of Pharmacy, University of Benin, Benin City, Nigeria
29.11.2007
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Subjects | |
Online Access | Get full text |
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Summary: | Objective - A process of melt granulation whereby the drug powder is
mixed with a melted wax has been used to modify the dissolution rates
of drug particles. The present study investigated how the incorporation
of hydrophobic materials (talc or magnesium stearate) in the core of
such granules may further retard drug release. Method - The hydrophobic
powder was mixed with the drug (paracetamol) powder prior to melt
granulation with Carnuba wax. Content of the hydrophobic material
varied from 0 to 50% but the content of wax was constant. Conventional
granules of paracetamol were formed by wet massing the paracetamol
powder with starch mucilage 20%w/v, followed by screening and drying.
The granules were subjected to dissolution test. Results - The results
indicated that melt granulation remarkably retarded the dissolution
rates of paracetamol granules. The rates can be further retarded by
inclusion of an internal hydrophobic material. The dissolution rate of
the conventional granules was 32%h-1 as against 11.6%h-1 (melt
granules) and 10.3%h-1 (melt granules with intragranular hydrophobic
agents, 5%w/w). Conclusion -The indication is that the inclusion of an
intragranular hydrophobic agent in the melt granules can be used to
obtain further control of drug release |
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ISSN: | 1596-5996 1596-5996 1596-9827 |
DOI: | 10.4314/tjpr.v6i3.14657 |