Glucocorticoid induced adrenal insufficiency

Adrenal insufficiency is characterised by inadequate glucocorticoid production by the adrenal gland.1 GC-AI occurs as a result of suppression of the hypothalamic-pituitary-adrenal axis secondary to prolonged exposure to glucocorticoids,2 and is among the most common types of adrenal insufficiency en...

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Bibliographic Details
Published inBMJ (Online) Vol. 379; p. e065137
Main Authors Garrahy, Aoife, Tomlinson, Jeremy W, Pal, Aparna
Format Journal Article
LanguageEnglish
Published England British Medical Journal Publishing Group 10.11.2022
BMJ Publishing Group LTD
Subjects
Adrenal cortex
Adrenal glands
Adrenal Insufficiency - chemically induced
Adrenal Insufficiency - diagnosis
Aldosterone
Drug dosages
Glucocorticoids
Glucocorticoids - adverse effects
Hormones
Humans
Hydrocortisone - therapeutic use
Hyponatremia
Hypothalamic-pituitary-adrenal axis
Hypothalamus
Laboratories
Metabolism
Nausea
Patient education
Pituitary
Practice
Prednisolone
Steroids
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Summary:Adrenal insufficiency is characterised by inadequate glucocorticoid production by the adrenal gland.1 GC-AI occurs as a result of suppression of the hypothalamic-pituitary-adrenal axis secondary to prolonged exposure to glucocorticoids,2 and is among the most common types of adrenal insufficiency encountered in clinical practice.2 In contrast to primary adrenal insufficiency, which is a disease of the adrenal cortex (eg, Addison’s disease), mineralocorticoid (aldosterone) secretion remains intact in GC-AI.
Bibliography:Easily Missed?
ISSN:1756-1833
1756-1833
DOI:10.1136/bmj-2021-065137