Thyroid storm after coronavirus disease 2019 mRNA vaccination in a patient with a history of Graves’ disease after coronavirus disease 2019 infection

• Published in: BMJ case reports Vol. 17; no. 6; p. e259796
• Main Authors: Saito, Masahiro, Iijima, Toshie, Kurai, Hidetaka, Aso, Yosimasa
• Format: Journal Article
• Language: English
• Published: England BMJ Publishing Group Ltd 04.06.2024; BMJ Publishing Group LTD
• Subjects: Case reports; Child; Coma; Consciousness; Coronaviruses; COVID-19; COVID-19 - complications; COVID-19 - prevention & control; COVID-19 vaccines; COVID-19 Vaccines - adverse effects; Delirium; Diarrhea; Endocrinology; Female; Fever; Graves Disease; High density lipoprotein; Hospitals; Humans; Hypercalcemia; Hyperthyroidism; Infections; Intensive care; Neutrophils; Phosphatase; Potassium; SARS-CoV-2; Scintigraphy; Thyroid Crisis - etiology; Thyroid disease; Thyroid diseases; Thyrotoxicosis; Ultrasonic imaging; Vaccination - adverse effects; COVID-19; Thyroid disease; Hyperthyroidism; Thyrotoxicosis
• ISSN: 1757-790X
• DOI: 10.1136/bcr-2024-259796

We report a case where the patient may have developed Graves’ disease after COVID-19 infection, and where the COVID-19 vaccination may have exacerbated the condition, inducing the onset of a thyroid storm. Although any association between the vaccine and the onset of thyroid disease is impossible to demonstrate through a single case, the antecedent COVID-19 infection and COVID-19 messenger ribonucleic acid vaccination may have synergistically contributed to the development of Graves’ disease followed by thyroid storm.