PO-383 Profile of serum heat shock protein-27 level in patients with salivary gland tumour

• Published in: ESMO open Vol. 3; no. Suppl 2; p. A378
• Main Authors: Zare, R, Andisheh-Tadbir, A, Moghadasi, N, Khademi, BI, Malekzadeh, M, Ardekani, S Torabi
• Format: Journal Article
• Language: English
• Published: Elsevier Ltd 01.07.2018
• ISSN: 2059-7029; 2059-7029
• DOI: 10.1136/esmoopen-2018-EACR25.892

IntroductionHeat shock protein 27 (HSP27) plays important roles in many cellular processes and also has been implicated in different types of diseases such as cancers. Objectives: This study aimed to evaluate the serum level of HSP27 in patients with salivary gland tumours and to determine if it had a correlation with prognosis or not.Material and methodsThis study was done on 60 patients with salivary gland tumour including 16 pleomorphic adenoma, 33 adenoid cystic carcinoma, 6 mucoepidermoid carcinoma, and 5 acinic cell carcinoma and 28 healthy control subjects. The control cases were healthy blood donors who matched the study group in age and sex. Serum samples were obtained from the clotted blood and Hsp27 concentrations were measured with Sandwich ELISA.Results and discussionsThe mean serum level of HSP27 was 3956.1±3830.1 in patients with malignant salivary gland tumour, which was significantly higher than that in benign salivary gland tumour (752.2±485.6) and healthy controls (602.3±575.8) (p<0.001). However, there was no significant difference in the HSP27 serum levels between the patients with benign salivary gland tumours and healthy controls (p=0.2). No correlation was detected between the mean serum levels of HSP27 and clinicopathologic factors such as age, sex, stage, nodal metastasis (p>0.05), except for the tumour size (p=0.04).ConclusionThe HSP27 concentration increased in patients with malignant salivary gland tumours. Moreover, the HSP27 level was correlated with tumour growth, invasiveness, and diagnosability. Yet, larger clinical studies are required to explore its prognostic value.