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By meticulously counting the number of labelled clones, and also quantifying the rate at which the inducing-mutations occurred, the authors were able to determine each crypt contained only between 5-7 active stem cells-far fewer than previously estimated from marker gene expression. In this prospect...

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Bibliographic Details
Published inGut Vol. 63; no. 2; pp. 362 - 363
Main Author McLean, Mairi H
Format Journal Article
LanguageEnglish
Published London BMJ Publishing Group LTD 01.02.2014
Subjects
Diet
Gastroenterology
Gene expression
Hepatology
Homeostasis
Inflammatory bowel disease
Liver cancer
Liver cirrhosis
Liver diseases
Metabolism
Mutation
Oxidative stress
Stem cells
Studies
Sucrose
Tumors
Uric acid
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Summary:By meticulously counting the number of labelled clones, and also quantifying the rate at which the inducing-mutations occurred, the authors were able to determine each crypt contained only between 5-7 active stem cells-far fewer than previously estimated from marker gene expression. In this prospective study, Oettl and colleagues collected blood samples (within 24 h of admission) from 67 consecutive cirrhotic patients hospitalised for acute decompensation and 18 consecutive non-cirrhotic patients with sepsis without evidence of cirrhosis admitted to intensive care unit.
ISSN:0017-5749
1468-3288
DOI:10.1136/gutjnl-2013-306499