GI highlights from the literature

• Published in: Gut Vol. 61; no. 2; pp. 319 - 320
• Main Author: McLean, Mairi H
• Format: Journal Article
• Language: English
• Published: London BMJ Publishing Group Ltd and British Society of Gastroenterology 01.02.2012; BMJ Publishing Group LTD
• Subjects: cancer; colon carcinogenesis; colonic polyps; colorectal adenomas; colorectal neoplasia; Cytokines; Disease; Gastroenterology; gut immunology; Hepatitis; Inflammatory bowel disease; Irritable bowel syndrome; Liver cancer; Lymphatic system; Molecular carcinogenesis; mucosal immunity; Pathogenesis; Population; premalignancy - GI tract; Rodents; Senescence; Studies; Surveillance; Transgenic animals; Transplants & implants; Tumor necrosis factor-TNF; Ultrasonic imaging
• ISSN: 0017-5749; 1468-3288
• DOI: 10.1136/gutjnl-2011-301745

When Alb-Cre;Ctnnb1flx/flx mice were crossed with transgenic mice harbouring the hepatitis B virus HBx gene, hepatic repopulation with β-catenin-expressing cells was more rapid as was the rate of tumour development. [...]experiments using a series of transgenic mice, cellular depletion and adoptive transfer strategies demonstrated CD4+ T cells and recruited monocyte-derived macrophages as key to senescence surveillance and tumour prevention.