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In this study, no correlation was seen between the serum markers of mitochondrial dysfunction or DNA damage and the PT, a much more useful prognostic marker. [...]it remains unclear whether the degree of mitochondrial dysfunction induced by acetaminophen excess has any bearing on clinical outcome. [...

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Bibliographic Details
Published inGut Vol. 61; no. 7; pp. 1095 - 1096
Main Author McLean, Mairi H
Format Journal Article
LanguageEnglish
Published London BMJ Publishing Group Ltd and British Society of Gastroenterology 01.07.2012
BMJ Publishing Group LTD
Subjects
Acquisitions & mergers
Analgesics
Aspirin
Bacteria
Bacterial infections
Defense
Deoxyribonucleic acid
DNA
Endoscopy
Gastroenterology
Immunology
Infections
Inflammatory bowel disease
Liver
Medical prognosis
Mitochondrial DNA
Multivariate analysis
Neutrophils
Pathogens
Patients
Proteins
Studies
Zinc
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Summary:In this study, no correlation was seen between the serum markers of mitochondrial dysfunction or DNA damage and the PT, a much more useful prognostic marker. [...]it remains unclear whether the degree of mitochondrial dysfunction induced by acetaminophen excess has any bearing on clinical outcome. [...]the reduction of bilirubin with no subsequent impact on survival may suggest incomplete treatment, wherein more sessions aiming at further reduction of bilirubin may have helped.
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ISSN:0017-5749
1468-3288
DOI:10.1136/gutjnl-2012-302763