POTENTIATION OF GROWTH HORMONE ACTIVITY IN SHEEP USING MCNCCLCNAL ANTIBODIES

ABSTRACT Monoclonal antibody CAll was raised against ovine GH; its effects on GH activity were examined in a target species relevant for animal production in vivo. The monoclonal antibody was found to enhance the galactopoietic response to exogenous GH in adult lactating ewes and also to potentiate...

Full description

Saved in:
Bibliographic Details
Published inJournal of endocrinology Vol. 120; no. 2; pp. R15 - R18
Main Authors Pell, J.M., Johnsson, I.D., Pullar, R.A., Morrell, D.J., Hart, I.C., Holder, A.T., Aston, R.
Format Journal Article
LanguageEnglish
Published BioScientifica 01.02.1989
Online AccessGet full text

Cover

More Information
Summary:ABSTRACT Monoclonal antibody CAll was raised against ovine GH; its effects on GH activity were examined in a target species relevant for animal production in vivo. The monoclonal antibody was found to enhance the galactopoietic response to exogenous GH in adult lactating ewes and also to potentiate the diabetogenic activity of both exogenous and endogenous GH in ewe lambs. Thus it was shown that GH activity may be manipulated above its usual dose-response range in normal, intact animals of commercial importance via immunological means.
ISSN:0022-0795
1479-6805
DOI:10.1677/joe.0.120R015