SOME ASPECTS OF CORTICOTROPHIN SECRETION IN THE TRAINED DOG

It has been demonstrated that conditions of »stressful« nature are associated with an increased concentration of plasma 17-hydroxycorticosteroids (Franksson & Gemzell, 1953) and that the secretion of corticotrophin (ACTH) is increased subsequent to »stress« (Sayers & Burks, 1955). Relatively...

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Bibliographic Details
Published inEuropean journal of endocrinology Vol. 29; no. 2; pp. 219 - 223
Main Authors Eik-Nes, Kristen B., Brizzee, Kenneth R.
Format Journal Article
LanguageEnglish
Published 01.10.1958
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Summary:It has been demonstrated that conditions of »stressful« nature are associated with an increased concentration of plasma 17-hydroxycorticosteroids (Franksson & Gemzell, 1953) and that the secretion of corticotrophin (ACTH) is increased subsequent to »stress« (Sayers & Burks, 1955). Relatively little is known concerning the mechanisms of ACTH release during »stress«. Fortier (1951) postulated the presence of a metabolic and a neurogenic type of »stress«. During the metabolic type of »stress« a substance or several substances may be released from injured tissue. These substances could, by their presence in the blood stream, influence the hypothalamus or the pituitary gland to discharge ACTH at an accelerated rate. Since adrenal hormones are »utilized« at a normal or a decreased rate during »stress« (Ulrich & Long, 1956, Firschein et al., 1957), it is necessary to look for other reaction pathways than the feed back theory (Sayers & Sayers, 1948) to explain why the secretion
ISSN:0804-4643
1479-683X
DOI:10.1530/acta.0.0290219