390 Can a heat-and-moisture exchanger attenuate inflammatory responses to exercise in sub-zero conditions?
BackgroundHeavy endurance training in sub-zero environments increases risk of exercise-induced asthma. Heat-and-moisture exchangers (HME) can prevent exercise-induced bronchoconstriction but it is not known whether they protect against inflammatory responses to exercise in healthy individuals.Object...
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Published in | British journal of sports medicine Vol. 55; no. Suppl 1; pp. A148 - A149 |
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Main Authors | , , , , , |
Format | Journal Article |
Language | English |
Published |
London
BMJ Publishing Group Ltd and British Association of Sport and Exercise Medicine
23.11.2021
BMJ Publishing Group LTD |
Subjects | |
Online Access | Get full text |
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Summary: | BackgroundHeavy endurance training in sub-zero environments increases risk of exercise-induced asthma. Heat-and-moisture exchangers (HME) can prevent exercise-induced bronchoconstriction but it is not known whether they protect against inflammatory responses to exercise in healthy individuals.ObjectiveTo investigate whether use of an HME during exercise in a sub-zero environment affects post-exercise inflammatory responses.DesignInvestigator-blind randomised crossover trial.SettingEnvironmental chamber at -15°C.Participants23 healthy, trained participants aged 18–53 (15 male, 8 female, VO2peak 57±6 and 50±4 mL/kg/min; mean±SD).InterventionsTwo experimental trials with and without HME, consisting of 30-min moderate-intensity running followed by a 4-min maximal running time-trial. Plasma samples were obtained pre- and 1h-post-exercise and analysed for a panel of 10 cytokines using a multiplex immunoassay.Main Outcome MeasurementsPlasma cytokine concentrations (GM-CSF, IL-1β, IL-4, IL-5, IL-6, IL-8, IL-10, IL-13, IL-17E/25, TNF-α). Data were log-transformed then analysed using two-way repeated-measures ANOVA; one participant was an extreme outlier and excluded.ResultsFive cytokines (GM-CSF, IL-1β, IL-4, IL-13, IL-17E/25) returned <20% concentrations within detection limits and were excluded from further analysis. The other cytokines returned >85% samples in range. IL-6, IL-8 and IL-10 increased after exercise (IL-6: F=36, p<0.0001; IL-8: F=39, p<0.0001; IL-10: F(1,21)=8.9, p=0.0072). There was a trend towards a greater post-exercise increase in IL-10 with HME (HME: median 0.062 (range -0.203–1.053) pg/mL; no-HME: 0.047 (-0.079–0.50) pg/mL; F=3.0, p=0.096). There were no significant interactions for other cytokines.ConclusionsUse of an HME during exercise in a sub-zero environment did not affect systemic pro- and anti-inflammatory cytokine responses to exercise. Local inflammatory markers in the lungs may be relevant to investigate in future studies. |
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Bibliography: | IOC World Conference on Prevention of Injury & Illness in Sport 2021 |
ISSN: | 0306-3674 1473-0480 |
DOI: | 10.1136/bjsports-2021-IOC.356 |