131 Triple-negative breast cancer: correlation between imaging and pathological findings

• Published in: International journal of gynecological cancer Vol. 29; no. Suppl 3; p. A62
• Main Authors: Zemni, I, Haddad, S, Adouni, O, Ben hassouna, J, Hechiche, M, Chargui, R, Rahal, K
• Format: Journal Article
• Language: English
• Published: Oxford by the International Gynecologic Cancer Society and the European Society of Gynaecological Oncology 01.09.2019; BMJ Publishing Group LTD
• Subjects: Breast cancer; Mammography; Ultrasonic imaging
• ISSN: 1048-891X; 1525-1438
• DOI: 10.1136/ijgc-2019-IGCS.131

ObjectivesOBJECTIVE:Although triple-negative breast cancer (TNBC) has been studied extensively in the oncology and pathology literature, there are few reports on imaging features. Emerging data suggest that imaging features of TNBC are substantially different from other primary breast cancer immunotypes.This study was designed to investigate the mammography and ultrasound findings of triple-negative breast cancer in a Tunsian population.MethodsFrom January 2009 to December 2013, mammography and ultrasound findings of 300 female patients with pathologically confirmed triple- breast cancers were retrospectively reviewed. We also reviewed pathological reports for information on the histological type, histological grade and the status of the biological markers.ResultsTriple-negative breast cancers showed a high histological grade ( Grade III =63%).On mammography, triple-negative breast cancers usually presented with a mass (97,6%) and a focal asymmetry was found in only 2 cases. A spiculated mass represented only 31% of cases. There were no cases of isolated micro-calcifications and associated microcalcifications were noted in 11% (N=33) of cases. The presence of microcalcification was not correlated with ductal carcinoma in situ associated to the infiltrating carcinoma.On ultrasound, the cancers were less frequently seen as non-mass lesions (14%), more likely to have circumscribed margins (66%), were markedly hypoechoic (79%) less likely to show posterior shadowing (12%) and with color doppler showing images of vessels within the tumor in 52% of cases.ConclusionsOur results suggest that the imaging findings might be useful in diagnosing triple-negative breast.