SAT0743-HPR Relation between serum albumin and physical performance and mobility in a community-based elderly people with osteoporosis

• Published in: Annals of the rheumatic diseases Vol. 77; no. Suppl 2; p. 1832
• Main Authors: Karapinar, M., Abit Kocaman, A., Kirdi, N., Balam Yavuz, B.
• Format: Journal Article
• Language: English
• Published: London BMJ Publishing Group LTD 01.06.2018
• Subjects: Aging; Albumin; Bone loss; Geriatrics; Mobility; Muscle strength; Older people; Osteoporosis; Rehabilitation; Risk factors; Walking; Women
• ISSN: 0003-4967; 1468-2060
• DOI: 10.1136/annrheumdis-2018-eular.6199

BackgroundOsteoporosis is a disease related to ageing and to other interacting variables, including genetic, metabolic, physical and nutritional factors. Several studies have reported that the serum albumin level in the elderly is significantly associated with muscle mass, muscle strength and functional capacity.1 Even among a nondisabled older persons, lower albumin concentrations have been shown to be independently associated with poorer performance as assessed by objective physical performance tests.2 ObjectivesThe purpose of this study was to investigate the association of serum albumin with physical performance (muscle strength and mobility ability) in patients with osteoporosis.MethodsFor the study, 168 patients with OP (98 women and 70 men) underwent an interview, physical performance testing and blood analysis. A total of patients followed by Hacettepe University Faculty of Medicine Department of Internal Medicine, Division of Geriatric Medicine Department and Geriatric Rehabilitation Unit. We excluded those who Mini Mental State score is under 24 points, Mini Nutritional Assessment Test score is under 11 and have advanced kidney disease. Physical performance was evaluated with Five Times Sit to Stand (FTSS) and Six Metre Walk Test (SMWT). Hand grip strength was measured with dynamometer. Pearson’s correlation coefficients were calculated for serum albumin, FTSS, SMWT and handgrip strength.ResultsParticipitants mean age of 72.73±6.34 years and BMI 22.56±2.98 kg/m² mean serum albumin concentration ±standart deviation was 41.9±3.5 g/L for women and 41.9±2.9 g/L for men. Serum albumin was associated significantly with physical performence (mobility and walking speed) and muscle strength (hand grip) were in men and women with OP(p<0.005).FTSSWalking SpeedHand Grip Serum albumin (men)P r 0.001−0.322 0.001−0.358 0.0220.255Serum albumin (women)P r 0.001−0.314 0.001−0.243 0.0260.205ConclusionsOur study demonstrated that a decrease in the serum albumin level is associated with a decrease in physical performance and muscle strength, although causality is still unclear.References[1] Hannan MT, et al. Risk factors for longitudinal bone loss in elderly men and women: the Framingham Osteoporosis Study. Journal of Bone and Mineral Research2000;15(4):710–720.[2] Cabrerizo S, Cuadras D, Gomez-Busto F, Artaza-Artabe I, Marín-Ciancas F, Malafarina V. Serum albumin and health in older people: review and meta analysis. Maturitas2015;81(1):17–27.Disclosure of InterestNone declared