AB0389 Hipertriglyceridemic-waist phenotype: a marker of cardiovascular risk in rheumatoid arthritis patients

• Published in: Annals of the rheumatic diseases Vol. 77; no. Suppl 2; p. 1362
• Main Authors: Guzmán Guzmán, I.P., Zaragoza-García, O., Navarro-Zarza, J.E., Maldonado-Anicacio, J., Castro-Alarcón, N., Parra-Rojas, I.
• Format: Journal Article
• Language: English
• Published: London BMJ Publishing Group LTD 01.06.2018
• Subjects: Cardiovascular diseases; Diabetes mellitus; Genotype & phenotype; Health risk assessment; Hyperuricemia; Medical personnel; Metabolic syndrome; Phenotypes; Rheumatic diseases; Rheumatoid arthritis; Uric acid; Vitamin D
• ISSN: 0003-4967; 1468-2060
• DOI: 10.1136/annrheumdis-2018-eular.5906

BackgroundThe risk of cardiovascular disease (CVD) is increased in rheumatoid arthritis (RA); about 50% of associated deaths in rheumatoid arthritis (RA) are attributed to CVD.1 Both traditional cardiovascular risk (CVR) factors and inflammation contribute to this risk. The hyperuricemia (HUC) and metabolic syndrome (MetS) are considered parameters of CVR, both closely related,2 and recently the hypertriglyceridemic-waist (HTGW) phenotype has been defined as well a marker to identify HUC in the general population.3 ObjectivesTo determine the prevalence of HTGW phenotype and to evaluate its association with CVR parameters among RA patients.MethodsHTGW phenotype was defined as waist girth ≥102 cm in male and ≥88 cm in female and TG >150 mg/dl in 250 patients diagnosed with RA according to the ACR/EULAR 2010 criteria. The levels of uric acid >5.5 mg/dL defined HUC. The MetS and its individual components (NCEP-ATPIII) were evaluated as parameters of CV risk.ResultsWe identified 51 AR patients (20.4%) whith HTGW phenotype. Adjusting for covariates in a logistic regression model, it was observed that the HTGW phenotype is associated with the presence of HUC (OR=6.14, p≤0.001), and MetS (OR=5.7, IC95%, 2.7–12.2, p≤0.001).ConclusionsHTGW is prevalent in RA patients from southern Mexico. The HTGW phenotype can be considered at low cost marker, used as a tool screening to predict high metabolic risk during the clinical course of the rheumatic disease.References[1] Goshayeshi L, Saber HR, Sahebari M, et al. Association between metabolic syndrome, BMI, and serum vitamin D concentrations in rheumatoid arthritis. Clin Rheumatol2012;31:1–7.[2] Abbasian M, Ebrahimi H, Delvarianzadeh M, et al. Association between serum uric acid (SUA) levels and metabolic syndrome (MetS) components in personnel of Shahroud university of medical sciences. Diabetes Metab Syndr2016;10:132–6.[3] Chen S, Guo X, Dong S, et al. Association between the hypertiglyceridemic waist phenotype and hyperuricemia: a cross-sectional study. Clin Rheumatol2017;36(5):1111–1119.AcknowledgementsNone.Disclosure of InterestNone declared