OP0068 Short term effects of ambient air pollution on osteoporotic hip fracture. an ecological study in a period of 16 years

• Published in: Annals of the rheumatic diseases Vol. 77; no. Suppl 2; p. 85
• Main Authors: Mazzucchelli, R., Pérez-Fernandez, E., Quirós, J., Crespí_Villarías, N., García-Vadillo, A.
• Format: Journal Article
• Language: English
• Published: London BMJ Publishing Group LTD 01.06.2018
• Subjects: Air pollution; Ecological studies; Fractures; Hip; Nitrogen dioxide; Osteoporosis; Particulate matter; Pollutants; Pollution; Sulfur dioxide; Weather
• ISSN: 0003-4967; 1468-2060
• DOI: 10.1136/annrheumdis-2018-eular.1515

ObjectivesTo examine the short-term effects of outdoor air pollution on the incidence of osteoporotic HFx in a southern European region.MethodsThis is a retrospective cohort study based on data from three databases. Daily HFx incidence was calculated using discharge data from the hospital of Alcorcón for the period 2000–2015. Daily weather conditions were compiled from records of the national meteorological station (AEMET). Daily air pollutant levels (mcg/m3) were calculated from data from the Ministry of Environment for the Madrid Community: sulfur dioxide (SO2), nitrogen monoxide (NO), nitrogen dioxide (NO2), ozone (O3) and particulate matter in suspension <2.5 µm (PM2.5) and <10 µm (PM10), for the same period. Pollutant concentrations were categorised into quartiles (Q1 to Q4, lowest to highest). Associations between HFx incidence and air pollutant levels were examined through Ggeneralized Additive Models (GAM) at a daily level with Poisson link function. Models were adjusted for a penalised spline function of time.Main outcome measuresDaily hospital admissions for hip fracture.ResultsHFx incidence showed a direct association with NO, NO2, PM2.5 and PM10 and inverse association with O3 levels. Incidence rate ratios for Q1vsQ2, Q1vsQ3 and Q1vsQ4 respectively were: 1.171 (1.103–1.244), 1.245 (1.173–1.322) and 1.331 (1.253–1.414) for NO; 1.057 (0.996–1.122), 1.185 (1.116–1.259) and 1.276 (1.199–1.357) for NO2; 1.028 (0.943–1.12), 1.092 (1.006–1.185) and 1.146 (1.049–1.253) for PM2.5; 1.083 (1.016–1.155), 1.099 (1.034–1.168) and 1.213 (1.136–1.294) for PM10; and 0.975 (0.914–1.04), 0.868 (0.815–0.924) and 0.814 (0.765–0.867) for O3. These associations persisted when the models were corrected for season, day of the week and weather conditions. When participants were stratified by age and sex, associations persisted only in women older than 75 years.ConclusionsA short-term effect was observed of several indicators of air pollution on hip fracture incidence. This is the first study that finds this association.Disclosure of InterestNone declared