SP0051 Clinical presentation of autoinflammatory diseases in children and adults: how not to miss these patients

Autoinflammatory diseases are diseases of the innate immune system, characterised by attacks of inflammation. The inflammatory attacks can manifest in a variety of forms; fever, is frequent, the skin and musculoskeletal system is often affected. Acute phase reactants are increased in almost all of t...

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Bibliographic Details
Published inAnnals of the rheumatic diseases Vol. 77; no. Suppl 2; p. 14
Main Author Ozen, S.
Format Journal Article
LanguageEnglish
Published London BMJ Publishing Group LTD 01.06.2018
Subjects
Antibodies
Arthritis
Children
Disease
Fever
Genetic screening
Immune system
Inflammation
Innate immunity
Musculoskeletal system
Plasma
Proteins
Psoriasis
Rheumatology
Skin
Ultrasonic imaging
Validity
Vascular diseases
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Summary:Autoinflammatory diseases are diseases of the innate immune system, characterised by attacks of inflammation. The inflammatory attacks can manifest in a variety of forms; fever, is frequent, the skin and musculoskeletal system is often affected. Acute phase reactants are increased in almost all of the patients. The autoinflammatory diseases can be classified according to their leading manifestations such as: those with periodic fevers (and other various features), those with pyogenic features, those with psoriasis, those with features of interferopathies and those with vasculopathy. With this large range of features these diseases are in the differential of many common diseases. Genetic testing is confirmatory but may not be widely available.The differentiating features of especially the common autoinflammatory diseases will be reviewed.Disclosure of InterestS. Ozen Consultant for: Novartis, Speakers bureau: SOBI
ISSN:0003-4967
1468-2060
DOI:10.1136/annrheumdis-2018-eular.7861