AB0735 Nailfold capillary counts correlate most with complications of systemic sclerodema in japanese patients

• Published in: Annals of the rheumatic diseases Vol. 77; no. Suppl 2; p. 1506
• Main Authors: Kondo, A., Dobashi, H., Kameda, T., Izumikawa, M., Nakashima, S., Shimada, H., Wakiya, R., Kato, M., Kadowaki, N.
• Format: Journal Article
• Language: English
• Published: London BMJ Publishing Group LTD 01.06.2018
• Subjects: Arthritis; Autoantibodies; Capillaries; Classification; Connective tissue diseases; Risk factors; Scleroderma; Systemic sclerosis; Ulcers
• ISSN: 0003-4967; 1468-2060
• DOI: 10.1136/annrheumdis-2018-eular.7510

BackgroundConnective tissue diseases (CTD) patients have various clinical manifestation including pulmonary hypertension (PH) and digital ulcer (DU). Especially, Raynaud’s phenomenon (RP) is one of the common symptoms. On the other hand, “abnormal nailfold capillaries” are important as the findings that suggest RP associated with CTD. They are included in one of the items of classification criteria for Sclerderma (SSc) in 2013 Classification Criteria for Systemic Sclerosis (ACR/EULAR) 1). Recently, some reports presented the usefulness of nailfold capillaroscopy (NFC) in SSc 2). NFC findings showed enlarged/giant capillaries, fresh or old haemorrhages, avascular areas, ramified/bushy capillaries. These findings are known as “scleroderma pattern” features. Additionally, there are some reports that nailfold capillary density in SSc related with DU, PH and interstitial pneumonia (IP).In this study, we clarify the association between nailfold capillary density and clinical manifestation by analysis of the case in our institution.ObjectivesTo clarify the association between nailfold capillary density and clinical manifestation.MethodsWe enrolled Japanese SSc patients from May 2016 to May 2017 in our institution.We measured total nailfold capillary count per 1 µm from second to fifth finger by NFC “OptiPiX Capillaroscopy Clinic 1.7.x”. In addition, we investigated relationship with NFC findings and clnical manifestation such as current and previous DU, PH and IP.ResultsWe enrolled 42 SSc patients. Total nailfold capillary counts significantly decreased, especially in SSc patients with, previous DU (ρ=−0.4122, p=0.0054), and PH (ρ=−0.3226, p=0.0023). In addition, there is significant difference between DU and existence of giant capillaries (ρ=0.3019 p=0.0464), existence of avascular areas (ρ=0.4057 p=0.0063). On the other hand, there is no significant difference between IP, PH and other “scleroderma pattern” features.ConclusionsOur study revealed that total nailfold capillary counts were associated with PH and DU in SSc patients. We suggest that nailfold capillary density may most predict complications with SSc patients.References[1] Markus Mueller, et al. Relation of Nailfold Capillaries and Autoantibodies to Mortality in Patients With Raynaud Phenomenon. Circulation. 133:509–517, 2016.[2] Maurizio Cutolo, et al. Nailfold Videocapillaroscopic Features and Other Clinical Risk Factors for Digital Ulcers in Systemic Sclerosis. Arthritis & Rheumatology. 68 (10): 2527–2539, 2016.Disclosure of InterestNone declared