Antibacterial activity of the aqueous extract of Thonningia sanguinea   against Extended-Spectrum-β-Lactamases (ESBL) producing Escherichia coli   and Klebsiella pneumoniae   strains

• Published in: Tropical journal of pharmaceutical research Vol. 6; no. 3
• Main Authors: N'guessan, J.D, Dinzedi, M.R, Guessennd, N, Coulibaly, A, Dosso, M, Djaman, A.J, Guede-Guina, F
• Format: Journal Article
• Published: Nigeria Pharmacotherapy Group, Faculty of Pharmacy, University of Benin, Benin City, Nigeria 29.11.2007
• Subjects: antimicrobial activity; E .coli; ESBL producing strains; Thonningia sanguinea
• ISSN: 1596-5996; 1596-5996

Purpose: The aim of this study was to evaluate the antimicrobial activity of Thonningia sanguinea against two sensitive and two multi-drug resistant (ESBL) Enterobacteria strains namely Escherichia coli and Klebsiella pneumoniae. Method: The confirmation of the ESBL producing strains was done by the double-disc synergy tests and the broth dilution method was used for the determination of the antimicrobial parameters (MIC and MBC) on these sensitive and ESBL producing strains. Results: The two sensitive strains had the same MIC and MBC values respectively 3.125 mg /ml and 12.50 mg/ml. The ESBL producing strains also had the same MIC of 6.25 mg /ml and MBC values of 25 mg/ml. The extract was bactericidal for all tested strains. Conclusion: The results suggest that the flowers of T. sanguinea can be used in association with antibiotics for alternative therapy of diseases caused by ESBL producing E .coli, K. pneumoniae.