P604 Is it the negative effects of serum vitamin deficiency of pregnant and lactating women on development of newborn neurological system can be avoided

• Published in: Archives of disease in childhood Vol. 104; no. Suppl 3; p. A393
• Main Authors: El, Çiğdem, Çelikkaya, Mehmet Emin
• Format: Journal Article
• Language: English
• Published: London BMJ Publishing Group LTD 01.06.2019
• Subjects: Breast feeding; Breastfeeding & lactation; Childrens health; Dietary supplements; Fetuses; Folic acid; Infants; Iron; Lactation; Neurotransmitters; Newborn babies; Nutrient deficiency; Pediatrics; Pregnancy; Prenatal experience; Ribonucleic acid; Risk factors; RNA; Serum levels; Swallowing; Vitamin B12; Vitamin deficiency; Womens health; Young Children
• ISSN: 0003-9888; 1468-2044
• DOI: 10.1136/archdischild-2019-epa.936

PurposeDeficiency of vitaminB12 if not diagnosed and treated early in infant period where the growth and development is very rapid which are very important for the construction of DNA/RNA and neurotransmitters, can lead to irreversible neuromotor pathologies.Material and methodBabies who were admitted with neurological complaints due to vitaminB12 deficiency between the dates of January2018-January2019 were included in this study. During the pregnancy and lactation intake of vitamin supplements, duration of breastfeeding and vitaminB12 levels were examined.ResultsIn our study, the mean age of 11babies was 2.6(2.1–3.4) months. Neurological findings; in 7babies there was swallowing disorder and in 4babies undeveloped ability to tonic neck reflex. The serum levels of vitaminB12 in babies were determined under 150pg/dl and in all mothers was under 250pg/dl. Although they were not regular receive iron and folate supplements during pregnancy, they did not never receiving vitaminB12 supplement during pregnancy-lactation.DiscussionVitaminB12 deficiency in babies may be associated with neurological findings and that delay in the diagnosis and treatment of infants may cause permanent neurological damage. In addition, maternal deficiency is considered to be an independent risk factor for the development of fetal neural tube defect. Deficiency of vitamin B12 in pregnant and lactating mothers is the main cause of Vitamin B12 deficiency in fetus and babies.ConclussionVitaminB12 deficiency is one of the causes of neurological retardation in babies (affect the development of the brain in the prenatal/postnatal period). In order to prevent this deficiency, healthy nutrition of the mother and taking the necessary vitamin supplements both the prenatal period and postnatal period should be provided. We think that should be given vitamin B12 routinely to all pregnant women like folic acid and iron supplementation.