EP314/#349  FYN expression is associated with sensitivity to platinum-based chemotherapy for ovarian serous carcinoma

• Published in: International journal of gynecological cancer Vol. 33; no. Suppl 4; pp. A206 - A207
• Main Authors: Uchikura, Eijiro, Fukuda, Takeshi, Noda, Takuya, Awazu, Yuichiro, Nanno, Shigenori, Imai, Kenji, Wada, Takuma, Yamauchi, Makoto, Yasui, Tomoyo, Sumi, Toshiyuki
• Format: Journal Article
• Language: English
• Published: Oxford BMJ Publishing Group Ltd 07.11.2023; BMJ Publishing Group LTD
• Subjects: Cancer; Chemotherapy; ePoster Viewing; Ovaries
• ISSN: 1048-891X; 1525-1438
• DOI: 10.1136/ijgc-2023-IGCS.377

IntroductionWe examined the correlation between Fyn expression and the sensitivity to platinum-based chemotherapy for ovarian serous carcinoma.MethodsWe reviewed 64 cases of ovarian serous carcinoma stage III-IV from 2005 to 2014. Cases were divided into two groups one group in which maximum debulking surgery followed by platinum-based chemotherapy was performed and did not recur within 6 months after initialization of chemotherapy (group A; n=32), and another group in which maximum debulking surgery followed by platinum-based chemotherapy was performed and recur within 6 months (group B; n=32). Fyn expression was examined immunohistochemically in paraffin-embedded sections using the avidin-biotin peroxidase complex method. This study was approved by the institutional review board in our facility.ResultsThe expression of Fyn was significantly higher in the group B than in the group A (p<0.01). Cases were divided into two groups according to a cutoff value of 6 which was calculated using a receiver operating characteristic curve: one group in which Fyn expression was low level (weighted score≤6, n=32), and another group in which Fyn expression was high level (weighted score≥8, n=32). Low Fyn expression group might be sensitive to platinum-based chemotherapy than high expression group (p=0.04). There was no significant difference in overall survival between two groups (P=0.05).Conclusion/ImplicationsExpression of Fyn might be associated with sensitivity to platinum-based chemotherapy for advanced ovarian serous carcinoma.