L-arginine and mitochondrial encephalomyopathy, lactic acidosis and stroke- like episodes (MELAS): a systematic review
BackgroundStroke-like episodes are a neurological emergency associated with MELAS syndrome. Recovery from stroke-like episodes occurs over a variable time period (hours to weeks) and no rigorous natural history studies of the condition have been undertaken. Despite this, L-arginine has been adopted...
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Published in | Journal of neurology, neurosurgery and psychiatry Vol. 93; no. 6; p. A97 |
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Main Authors | , , , , , , |
Format | Journal Article |
Language | English |
Published |
London
BMJ Publishing Group Ltd
01.06.2022
BMJ Publishing Group LTD |
Subjects | |
Online Access | Get full text |
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Summary: | BackgroundStroke-like episodes are a neurological emergency associated with MELAS syndrome. Recovery from stroke-like episodes occurs over a variable time period (hours to weeks) and no rigorous natural history studies of the condition have been undertaken. Despite this, L-arginine has been adopted as both acute treatment and prophylaxis. We sought to systematically evaluate the evidence for L-argi- nine use.MethodsWe searched 5 databases published between inception and 15/01/2021. The inclusion criteria were 1) use of L-arginine in acute or chronic management of stroke-like episodes; 2) genetically confirmed mitochondrial disease. GRADE was used to assess the quality of evidence. Prospero registra- tion: CRD42020181230.ResultsOf 3,541 articles identified, 37 were eligible (3 open-label, 1 retrospective cohort, and 33 case reports). All studies were rated as very low-quality evidence. Open-label trials reported clinical response based on the subjective improvement of symptoms within 24 hours of treatment. Thirty-seven patients received L-arginine acutely in other studies. Clinical response was reported over variable time points (27/37); though confounders such as anticonvulsants (19/37) were not considered. Efficacy of chronic L-arginine supplementation cannot be established in most studies.ConclusionEvidence for the use of L-arginine in MELAS syndrome is poor, and is associated with a high risk of bias.yi.ng@ncl.ac.uk19 |
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Bibliography: | Inflammation & Neurogenetics: 04 |
ISSN: | 0022-3050 1468-330X |
DOI: | 10.1136/jnnp-2022-ABN.315 |